Description:
This is genetically defined mutant Syrian hamster. The spontaneous mutation was discovered in the early 1960's and was perpetuated ever since. This mutation affect all muscle systems, namely smooth muscle, skeletal muscle and cardiac muscle. The molecular basis for the genetic defect has been identified as mutation in the delta sarcoglycan gene.
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Applications
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Cardiomyopathy
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Muscular dystrophy
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Arrhythmia
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Heart failure
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Rend disease
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Gene therapy
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Gait abnormalities
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ECG abnormalities
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Reference:
Homburger, F., et al. 1962. Arch. Intern. Med. 110: 660-662.
Historical Reference Sampling Myopathics
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